PLLA-Based Endoprosthesis Coated with Exosome-Mimetic Nano-Vesicles for the Treatment of Critical Limb Ischemia

PROJECT COST:

115 260 $

PRIMA CONTRIBUTION:

52 260 $

PROJECT DETAILS:

Bioresorbable stents may induce inflammatory responses and adverse tissue reactions in the areas surrounding the implant after implantation. Researchers at Chung-Ang University have developed a nano-vesicular exosome-mimetic coating with the potential to reduce inflammation and promote tissue regeneration. If its effectiveness is conclusively demonstrated, medical devices incorporating this technology could lead to improved patient outcomes and faster recovery times.

The objective of this project is to design, develop, manufacture, and evaluate a poly(L-lactic acid) (PLLA)-based stent. This endoprosthesis is distinguished by a bio-ink containing nano-vesicles applied as a surface coating. The proposed system is expected to support the vascular wall while promoting regeneration of vascular tissue affected by critical limb ischemia. The biomechanical properties of the prosthesis, as well as its performance, will be assessed using both in vitro and in vivo models.

For the industrial partners, Dotter and Seido, the project offers the potential to increase acceptance of bioresorbable stents, a market that has faced challenges due to limitations observed in products from other manufacturers. The collaboration will also provide access to the specialized expertise of the two academic partners.

For Quebec, the collaboration between McGill University, Dotter, and researchers from Chung-Ang University enables access to advanced expertise in polymer endoprosthesis fabrication and nano-vesicle coating technologies. McGill will contribute design and research expertise, while Seido’s leadership in polymer endoprosthesis machining is expected to strengthen its market position in this field.